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heterotopic breast epithelial inclusion of the heart

Wednesday 1 September 2010

Although the heterotopic breast tissue on the skin along the milk line is well recognized, it has also been described to involve internal organs including the heart.

Synopsis

- heterotopic breast epithelial inclusion of the heart
- focally microcystic ductal/tubular structures lined by a biphasic pattern of cuboidal to columnar apical epithelial cells with an outer layer of flattened basal cells.

  • These glandular structures are arranged in vaguely lobular and focally infiltrative patterns in the epicardium and interstitium.
  • No architectural or cytologic atypia or mitotic or apoptotic figures.
  • The apical epithelial cells are immunoreactive for pankeratin, cytokeratin (CK) 7, estrogen receptor, progesterone receptor, gross cystic disease fluid protein-15, and negative for CK20, calretinin, Wilms’ tumor suppressor gene (WT1), CD31, suggestive of mammary epithelial differentiation.
  • The basal cells are immunoreactive for pankeratin, CK7, CK5/6, D2-40, smooth-muscle actin and focally S100, suggestive of myoepithelial differentiation.

References

- Heterotopic Breast Epithelial Inclusion of the Heart: Report of a Case. Sasaki K, Parwani AV, Demetris AJ, Sasatomi E. Am J Surg Pathol. 2010 Aug 16. PMID: 20717001