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INHA

HGNC:6065 2q33-qter MIM.147380

Thursday 13 November 2003

inhibin A, inhibin alpha subunit; inhibin, alpha

IHCDB

Definition: Inhibin is a polypeptide hormone secreted by granulosa cells of the ovary and Sertoli cells of the testis.

The inhibin-alpha subunit is also expressed in other human tissues such as the prostate, brain, and adrenal cortex, as well as cells of the fetoplacental unit.

Immunochemistry

The alpha-inhibin immunohistochemical stain is used as a differential marker for adrenocortical tumors, placental and gestational trophoblastic lesions, and sex cord stromal tumors, such as granulosa cell tumors, luteinized thecomas, and Leydig cell tumors.

- pancreatic tumors

  • In pancreatic tumors, positive staining was only reported in luteinizing cells of the ovarian-like stroma of mucinous cystic neoplasms.

- gonadal tumors

- some carcinomas
- adrenal cortical tumors (12808065)

  • adrenal cortical carcinoma

- hemangioblastoma (12883249)
- other tumors

IHC examples

- INHA+ sertoli cells in gonadoblastoma

See also

- inhibins (INHs)

  • INHA
  • INHBs
    • INHBA
    • INHBB
    • INHBC

References

- Kosmahl M, Wagner J, Peters K, Sipos B, Kloppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol. 2004 Mar;28(3):339-46. PMID: 15104296

- Hildebrandt RH, Rouse RV, Longacre TA. Value of inhibin in the identification of granulosa cell tumors of the ovary. Hum Pathol. 1997 Dec;28(12):1387-95. PMID: 9416696