HGNC:6065 2q33-qter MIM.147380
Thursday 13 November 2003
Definition: Inhibin is a polypeptide hormone secreted by granulosa cells of the ovary and Sertoli cells of the testis.
The inhibin-alpha subunit is also expressed in other human tissues such as the prostate, brain, and adrenal cortex, as well as cells of the fetoplacental unit.
The alpha-inhibin immunohistochemical stain is used as a differential marker for adrenocortical tumors, placental and gestational trophoblastic lesions, and sex cord stromal tumors, such as granulosa cell tumors, luteinized thecomas, and Leydig cell tumors.
In pancreatic tumors, positive staining was only reported in luteinizing cells of the ovarian-like stroma of mucinous cystic neoplasms.
- adrenal cortical carcinoma
Kosmahl M, Wagner J, Peters K, Sipos B, Kloppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol. 2004 Mar;28(3):339-46. PMID: 15104296