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INHA

HGNC:6065 2q33-qter MIM.147380

Thursday 13 November 2003

IHCDB

Definition: Inhibin is a polypeptide hormone secreted by granulosa cells of the ovary and Sertoli cells of the testis.

The inhibin-alpha subunit is also expressed in other human tissues such as the prostate, brain, and adrenal cortex, as well as cells of the fetoplacental unit.

Immunochemistry

The alpha-inhibin immunohistochemical stain is used as a differential marker for adrenocortical tumors, placental and gestational trophoblastic lesions, and sex cord stromal tumors, such as granulosa cell tumors, luteinized thecomas, and Leydig cell tumors.

In pancreatic tumors, positive staining was only reported in luteinizing cells of the ovarian-like stroma of mucinous cystic neoplasms.

- sex cord stromal tumors (SCSTs)
- some carcinomas
- adrenal cortical tumors (12808065)

  • adrenal cortical carcinoma

- hemangioblastoma (12883249)
- other tumors

See also

- inhibins (INHs)

  • INHA
  • INHBs
    • INHBA
    • INHBB
    • INHBC

References

- Kosmahl M, Wagner J, Peters K, Sipos B, Kloppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol. 2004 Mar;28(3):339-46. PMID: 15104296

- Hildebrandt RH, Rouse RV, Longacre TA. Value of inhibin in the identification of granulosa cell tumors of the ovary. Hum Pathol. 1997 Dec;28(12):1387-95. PMID: 9416696