HGNC:6065 2q33-qter MIM.147380
Thursday 13 November 2003
inhibin A, inhibin alpha subunit; inhibin, alpha
The inhibin-alpha subunit is also expressed in other human tissues such as the prostate, brain, and adrenal cortex, as well as cells of the fetoplacental unit.
The alpha-inhibin immunohistochemical stain is used as a differential marker for adrenocortical tumors, placental and gestational trophoblastic lesions, and sex cord stromal tumors, such as granulosa cell tumors, luteinized thecomas, and Leydig cell tumors.
- In pancreatic tumors, positive staining was only reported in luteinizing cells of the ovarian-like stroma of mucinous cystic neoplasms.
- sex cord stromal tumors (SCSTs)
- Sertoli cells in gonadoblastoma
- adrenal cortical carcinoma
INHA+ sertoli cells in gonadoblastoma
Kosmahl M, Wagner J, Peters K, Sipos B, Kloppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol. 2004 Mar;28(3):339-46. PMID: 15104296
Hildebrandt RH, Rouse RV, Longacre TA. Value of inhibin in the identification of granulosa cell tumors of the ovary. Hum Pathol. 1997 Dec;28(12):1387-95. PMID: 9416696