high-grade fimbrial-ovarian carcinoma
Thursday 8 July 2010
High-grade endometrioid and serous carcinomas of the ovary and fallopian tube are responsible for the majority of cancer deaths and comprise a spectrum that includes early or localized (tubal intraepithelial carcinoma) and advanced (invasive or metastatic) disease.
Three groups can be defined:
(1) classic serous carcinomas
(2) mixed serous and endometrioid carcinomas
(3) endometrioid carcinomas
PAX2 and PTEN, in addition to p53 and p16(ink4), comprise a potentially important gene combination in high-grade pelvic carcinogenesis.
High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression. Roh MH, Yassin Y, Miron A, Mehra KK, Mehrad M, Monte NM, Mutter GL, Nucci MR, Ning G, McKeon FD, Hirsch MS, Wa X, Crum CP. Mod Pathol. 2010 Jun 18. PMID: 20562848