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portal hypertensive gastropathy

Wednesday 28 April 2010

PHG, Congestive Gastropathy

Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are unusual but important causes of gastrointestinal bleeding with characteristic endoscopic appearances and critically different therapies.

However, overlapping features and poor endoscopic-histologic correlation make their distinction challenging.

In PHG, the increased vascularity may be subtle in an inflammatory background; vascular markers may serve as adjunct markers for identifying the aberrant vessels.


- markedly dilatedand congested mucosal capillaries.
- markedly dilated spaces lined by endothelial cells and filled with unclotted blood


- CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: An immunohistochemical and digital morphometric study. Westerhoff M, Tretiakova M, Hovan L, Miller J, Noffsinger A, Hart J. Am J Surg Pathol. 2010 Apr;34(4):494-501. PMID: 20351488