Thursday 22 April 2010
Definition: Parthenogenesis is a process used by some lizards and birds to reproduce without the need of a male.
For mammalians, the term is commonly referred to embryonic development of eggs activated artificially or aberrantly without fertilization by a sperm.
Although mammalian parthenocytes normally can not develop into a full organism, they could, in theory, provide a source to derive ES cells with an exact match to the oocyte donor’s genome (both nuclear and mitochondrial).
It is also possible that parthenogenesis could provide a source of cells that are homozygous for major histocompatibility alleles (such as HLA-A, B or DRB), thereby allowing partial MHC matching to a substantial population of unrelated transplant recipients.
Nonetheless, establishing human PES cells (referred as hPES cells here) is an important milestone, not only for a potential source of human stem cells with improved histocompatibility, but also for future basic studies of epigenetic regulation and developmental/stem cell biology.
Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis. Liu N, Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L. J Mol Cell Biol. 2010 Dec;2(6):333-44. PMID: 20926514 (Free)
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