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desmoplastic medulloblastoma

Wednesday 21 April 2010

Medulloblastoma is a malignant invasive embryonal tumor of the cerebellum, representing 15-30% of pediatric brain tumors.

An i(17q) abnormality appears in 40% of medulloblastomas, and usually not as a sole aberration; however, cytogenetic data for medulloblastoma are limited.

Cytogenetics

- t(3;22)(q12;p11.1) (20082855)

  • This unbalanced translocation leads to partial trisomy of 3q. (20082855)

References

- Derivative (22)t(3;22)(q12;p11.1) in desmoplastic medulloblastoma. Manor E, Bodner L, Kachko P, Kapelushnik J. Cancer Genet Cytogenet. 2010 Jan 15;196(2):175-8. PMID: 20082855