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acute pulmonary histoplasmosis

Thursday 15 April 2010

The histologic features of acute pulmonary histoplasmosis are not well described as this form of the disease is rarely biopsied. Acute pulmonary histoplasmosis may cause a lymphohistiocytic infiltrate with necrosis and vasculitis that is suggestive of LYG. This observation emphasizes the importance of examining special stains for organisms before diagnosing grade 1 LYG. (20351490)

Differential diagnosis

- other infections

  • Pneumocystic carinii infection
  • Blastomyces dermatidis
  • Torulopsis glabrata
  • Penicillium marneffei

- lymphomatoid granulomatosis (20351490)

See also

- pulmonary histoplasmosis


- Biopsy findings in acute pulmonary histoplasmosis: unusual histologic features in 4 cases mimicking lymphomatoid granulomatosis. Mukhopadhyay S, Katzenstein AL. Am J Surg Pathol. 2010 Apr;34(4):541-6. PMID: 20351490