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chronic idiopathic neutropenia

Tuesday 30 March 2010

Chronic idiopathic neutropenias are rare disorders for which recent discoveries have highlighted mechanisms and consequences.

An inflammatory bone marrow milieu has been shown to be a major contributor to the pathophysiology of chronic idiopathic neutropenia. Activated T-lymphocytes with myelosuppressive properties and pro-apoptotic mediators, such as IFNgamma, TNFalpha, Fas-ligand and TGFbeta1 result in accelerated apoptosis of granulocytic progenitor cells.

Decreased levels of the anti-inflammatory cytokine IL-10 further disturb the balance between survival and pro-apoptotic mediators in chronic idiopathic neutropenia.

See also

- severe congenital neutropenias


- Chronic idiopathic neutropenias and severe congenital neutropenia. Palmblad J, Papadaki HA. Curr Opin Hematol. 2008 Jan;15(1):8-14. PMID: 18043240