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Sjögren disease

Wednesday 24 March 2010

primary Sjögren’s syndrome; Goujerot-Sjögren disease; Sjögren syndrome

Sjogren’s syndrome causes keratoconjunctivitis sicca and xerostomia. It can also cause other exocrine abnormalities such as vaginal dryness, bronchitis, and affect other organs.

Anti-SS-A (Ro) and anti-SS-B (La) antibodies

Anti-SS-A(Ro) antibodies are found in many autoimmune disorders, such as SLE, subacute cutaneous lupus, neonatal lupus, ANA negative lupus, Sjogren’s syndrome, primary biliary cirrhosis, chronic active hepatitis, and rheumatoid arthritis.

Anti-SS-B (La) is far more specific for Sjogren’s syndrome than anti-SSA. It is also found in SLE.

Digital case

- HPC:309 : Salivary gland in Sjögren syndrome

Synopsis

- pulmonary Sjögren disease

  • lymphoproliferative disorders of the lung
    • lymphocytic interstitial pneumonia (LIP)
    • follicular bronchiolitis
    • pulmonary nodular lymphoid hyperplasia (PNLH)
    • low-grade lymphomas

- salivary Sjögren disease

References

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