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Epstein-Barr virus-negative post-transplant lymphoproliferative disease

Wednesday 10 March 2010

Post-transplant lymphoproliferative disorders (PTLDs) are usually but not invariably associated with Epstein-Barr virus (EBV). The reported incidence, however, of EBV-negative PTLDs varies widely, and it is uncertain whether they should be considered analogous to EBV-positive PTLDs and whether they have any distinctive features.

EBV-negative PTLDs have distinct features, but some do respond to decreased immunosuppression, similar to EBV-positive cases, suggesting that EBV positivity should not be an absolute criterion for the diagnosis of a PTLD.

References

- Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity? Nelson BP, Nalesnik MA, Bahler DW, Locker J, Fung JJ, Swerdlow SH. Am J Surg Pathol. 2000 Mar;24(3):375-85. PMID: 10716151