Sunday 7 March 2010
Empowered by technology and sampling efforts designed to facilitate genome-wide association mapping, human geneticists are now studying the geography of genetic variation in unprecedented detail.
With high genomic coverage and geographic resolution, these studies are identifying loci with spatial signatures of selection, such as extreme levels of differentiation and correlations with environmental variables.
Collectively, patterns at these loci are beginning to provide new insights into the process of human adaptation.
Spatial patterns of variation due to natural selection in humans. Novembre J, Di Rienzo A. Nat Rev Genet. 2009 Nov;10(11):745-55. PMID: #19823195#