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response to hypoxia

Sunday 7 March 2010

The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells.

The hypoxic-sensitive regulation of gene expression allows information about the oxygen status to be converted into appropriate cellular responses.

Although there is a core transcriptional pathway, the signalling cascade can be modified to allow diversity and specificity in the transcriptional output.

See also

- hypoxic signaling
- cellular hypoxic response

References

- Generating specificity and diversity in the transcriptional response to hypoxia. Lendahl U, Lee KL, Yang H, Poellinger L. Nat Rev Genet. 2009 Dec;10(12):821-32. PMID: 19884889