Sunday 7 March 2010
Transcriptomics studies often rely on partial reference transcriptomes that fail to capture the full catalogue of transcripts and their variations.
However, transcriptome assembly from billions of RNA-seq reads, which are often very short, poses a significant informatics challenge.
Next-generation transcriptome assembly. Martin JA, Wang Z. Nat Rev Genet. 2011 Sep 7;12(10):671-82. PMID: 21897427