16q13 MIM.156353 HGNC:7399 Entrez:4495
Tuesday 23 February 2010
GeneRIFs (February 2010)
p16INK4A, DAPK1, PTEN and MT1G genes were not frequently methylated in the stage I non-small cell lung cancer in China.
MT1G acts as a tumor suppressor gene in hepatocellular carcinoma
Promoter methylation and differential gene expression of five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated by sequencing of bisulfite-modified DNA and real-time reverse transcriptase PCR, respectively.
Using a panel of four genes (AHRR, p16INK4a, MT1G, and CLDN3) resulted in sensitivity and specificity of 50% and 68%, respectively and may have utility for early detection of esophageal squamous dysplasia and early ESCC.
MT1G is hypermethylated in renal cell carcinoma.
Induction of the hMT1G promoter by VEGF and heavy metals occurs through the utilization of different transcription factors.
Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity.
Loss of metallothionein 1G function due to hypermethylation of its promoter leads to athogenesis of papillary thyroid carcinoma
MT1G hypermethylation: a potential prognostic marker for hepatoblastoma. (#20032811#)
MT1G hypermethylation: a potential prognostic marker for hepatoblastoma. Sakamoto LH, de Camargo B, Cajaiba M, Soares FA, Vettore AL. Pediatr Res. 2009 Dec 21. PMID: #20032811#