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plasmocytic Castleman disease

Wednesday 6 January 2010

plasma cell type of Castleman disease; plasma cell variant

Digital case

- HPC:335 : Plasmocytic Castleman disease (associated to Kaposi sarcoma)

Images

- https://twitter.com/KyleBradleyMD/status/732318591555645440

Synopsis

- diffuse plasma cell proliferation in interfollicular tissue
- follicular hyperplasia without vascular hyaline changes
- interfollicular region showing a massive infiltration by plasma cells. Some of these plasma cells show multinucleation and mild nuclear atypia.
- Sometimes numerous Russell bodies
- Hyaline-vascular changes in follicles inconspicuous or absent
- Often deposition of an amorphous acidophilic material that probably contains fibrin and immune complexes in center of follicles
- Overall appearance reminiscent of that in lymph nodes in rheumatoid arthritis

Association

- HHV8-associated Kaposi sarcoma

Physiopathology

- Abundant expression of interleukin-6: thought to be responsible for plasma cell infiltration.

Differential diagnosis

- Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia:
- Oriental disease closely related to plasma cell type, but apparently not identical.

See also

- Castleman disease

References

- Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents. Leroy S, Moshous D, Cassar O, Reguerre Y, Byun M, Pedergnana V, Canioni D, Gessain A, Oksenhendler E, Fieschi C, Mahlaoui N, Rivière JP, Herbigneaux RM, Muszlak M, Arnaud JP, Fischer A, Picard C, Blanche S, Plancoulaine S, Casanova JL. Pediatrics. 2012 Jan;129(1):e199-203. PMID: 22157133