Tuesday 11 November 2003
The shapes of eukaryotic cells and ultimately the organisms that they form are defined by cycles of mechanosensing, mechanotransduction and mechanoresponse.
Local sensing of force or geometry is transduced into biochemical signals that result in cell responses even for complex mechanical parameters such as substrate rigidity and cell-level form. These responses regulate cell growth, differentiation, shape changes and cell death.
Beningo KA, Wang YL. Flexible substrata for the detection of cellular traction forces. Trends Cell Biol. 2002 Feb;12(2):79-84. PMID: 11849971
Muller U, Littlewood-Evans A. Mechanisms that regulate mechanosensory hair cell differentiation. Trends Cell Biol. 2001 Aug ;11(8):334-42. PMID : 11489639