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mechanosensitivity

Tuesday 11 November 2003

The shapes of eukaryotic cells and ultimately the organisms that they form are defined by cycles of mechanosensing, mechanotransduction and mechanoresponse.

Local sensing of force or geometry is transduced into biochemical signals that result in cell responses even for complex mechanical parameters such as substrate rigidity and cell-level form. These responses regulate cell growth, differentiation, shape changes and cell death.

See also

- mechanotransduction
- mechanoresponse

References

- Vogel V, Sheetz M. Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol. 2006 Apr;7(4):265-75. PMID: #16607289#

- Estes BT, Gimble JM, Guilak F. Related Articles, Links
Mechanical signals as regulators of stem cell fate.
Curr Top Dev Biol. 2004;60:91-126. PMID: #15094297#

- Olson MF. Contraction reaction: mechanical regulation of Rho GTPase. Trends Cell Biol. 2004 Mar;14(3):111-4. PMID: #15055199#

- Bershadsky AD, Balaban NQ, Geiger B. Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol. 2003;19:677-95. PMID: #14570586#

- Beningo KA, Wang YL. Flexible substrata for the detection of cellular traction forces. Trends Cell Biol. 2002 Feb;12(2):79-84. PMID: #11849971#

- Muller U, Littlewood-Evans A. Mechanisms that regulate mechanosensory hair cell differentiation. Trends Cell Biol. 2001 Aug ;11(8):334-42. PMID : #11489639#