Tuesday 11 November 2003
Local sensing of force or geometry is transduced into biochemical signals that result in cell responses even for complex mechanical parameters such as substrate rigidity and cell-level form. These responses regulate cell growth, differentiation, shape changes and cell death.
Vogel V, Sheetz M. Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol. 2006 Apr;7(4):265-75. PMID: 16607289
Olson MF. Contraction reaction: mechanical regulation of Rho GTPase. Trends Cell Biol. 2004 Mar;14(3):111-4. PMID: 15055199
Beningo KA, Wang YL. Flexible substrata for the detection of cellular traction forces. Trends Cell Biol. 2002 Feb;12(2):79-84. PMID: 11849971
Muller U, Littlewood-Evans A. Mechanisms that regulate mechanosensory hair cell differentiation. Trends Cell Biol. 2001 Aug ;11(8):334-42. PMID : 11489639