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solitary form of Castleman disease

Wednesday 6 January 2010


- Presents as a mass:

  • most common in mediastinum
  • also described in: neck, lung, axilla, mesentery, broad ligament, retroperitoneum, soft tissues of extremities, nasopharynx, meninges, several other sites

- morphological types

  • >90% are hyaline-vascular type Castleman disease: usually asymptomatic
  • ≈10% plasma cell type Castleman disease: often associated with: fever, anemia, elevated erythrosedimentation rate, hypergammaglobulinemia, hypoalbuminemia

- Sometimes microscopic changes suggesting early stage of same process in adjacent nodes


- Round
- Well-circumscribed
- Cut surface: solid, gray
- can measure ≥15cm diameter

See also

- Castleman disease