- Human pathology

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Wednesday 6 January 2010, by JA


- SOX11 immunostaining in confirming diagnosis of mantle cell #lymphoma on FNA samples

Diagnostic use

- mantle cell lymphoma (MCL)

  • SOX11 expression has been shown to be useful in the diagnosis of mantle cell lymphoma (MCL), including cyclin D1-negative MCL with typical morphology.
  • Routine use of SOX11 in cases of suspected CD5 DLBCL might help identify additional cases of cyclin D1-negative blastoid MCL.
  • SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. (26949534)

Open references

- SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. Narurkar R, Alkayem M, Liu D. Biomark Res. 2016 Mar 3;4:6. doi : 10.1186/s40364-016-0060-9 PMID: 26949534 (Free)


- Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. Zeng W, Fu K, Quintanilla-Fend L, Lim M, Ondrejka S, Hsi ED. Am J Surg Pathol. 2012 Feb;36(2):214-9. PMID: 22251940

- Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. Chen YH, Gao J, Fan G, Peterson LC. Mod Pathol. 2010 Jan;23(1):105-12. PMID: 19801969

- The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival. Wang X, Asplund AC, Porwit A, Flygare J, Smith CI, Christensson B, Sander B. Br J Haematol. 2008 Oct;143(2):248-52. PMID: 18729857

- Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Sock E, Rettig SD, Enderich J, Bösl MR, Tamm ER, Wegner M. Mol Cell Biol. 2004 Aug;24(15):6635-44. PMID: 15254231