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SOX11

Wednesday 6 January 2010, by JA

SOX11 expression has been shown to be useful in the diagnosis of mantle cell lymphoma (MCL), including cyclin D1-negative MCL with typical morphology.

Routine use of SOX11 in cases of suspected CD5 DLBCL might help identify additional cases of cyclin D1-negative blastoid MCL.

References

- Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. Zeng W, Fu K, Quintanilla-Fend L, Lim M, Ondrejka S, Hsi ED. Am J Surg Pathol. 2012 Feb;36(2):214-9. PMID: #22251940#

- Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. Chen YH, Gao J, Fan G, Peterson LC. Mod Pathol. 2010 Jan;23(1):105-12. PMID: #19801969#

- The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival. Wang X, Asplund AC, Porwit A, Flygare J, Smith CI, Christensson B, Sander B. Br J Haematol. 2008 Oct;143(2):248-52. PMID: #18729857#

- Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Sock E, Rettig SD, Enderich J, Bösl MR, Tamm ER, Wegner M. Mol Cell Biol. 2004 Aug;24(15):6635-44. PMID: #15254231#