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multilocular cystic renal cell carcinoma

Thursday 10 December 2009, by JA

Multilocular cystic renal cell carcinoma is an uncommon low grade renal cell carcinoma with unique morphologic features. Its cytogenetic characteristics have not been fully investigated. Its relationship to typical clear cell renal cell carcinoma is uncertain.

Molecular biology

Chromosome 3p deletion is 74%) of the multilocular cystic renal cell carcinoma cases, vs 89% in clear cell renal cell carcinoma. There is no difference in the status of chromosome 3p deletion between clear cell renal cell carcinoma and multilocular cystic renal cell carcinoma. These results support the concept that multilocular cystic renal cell carcinoma as a subtype of clear cell renal cell carcinoma. (#20348877#)

References

- Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma. Halat S, Eble JN, Grignon DJ, Lopez-Beltran A, Montironi R, Tan PH, Wang M, Zhang S, Maclennan GT, Cheng L. Mod Pathol. 2010 Mar 26. [Epub ahead of print]. PMID: #20348877#

- Multilocular cystic renal cell carcinoma : a report of 45 cases of a kidney tumor of low malignant potential. Suzigan S, López-Beltrán A, Montironi R, Drut R, Romero A, Hayashi T, Gentili AL, Fonseca PS, deTorres I, Billis A, Japp LC, Bollito E, Algaba F, Requena-Tapias MJ. Am J Clin Pathol 2006 Feb;125(2):217-22. PMID: #16393684#

- Multilocular cystic renal cell carcinoma: a series of 12 cases and review of the literature. Nassir A, Jollimore J, Gupta R, Bell D, Norman R. Urology. 2002 Sep;60(3):421-7. Review. PMID: #12350478#