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serous tubal intraepithelial carcinoma

Sunday 15 November 2009

A recent characterization of serous tubal intraepithelial carcinoma (STIC) and of the p53 signature suggested that HG-PSC may follow a stepwise progression on cellular and molecular levels. (#19898227#)

HMGA2

In invasive carcinoma, HMGA2 overexpression is correlated with p53, indicating the role of HMGA2 in p53 mediated tumor progression. Immunoreactivity for HMGA2 may lead to a novel, useful biomarker to complement p53 in the detection of early-stage serous carcinoma. (#19898227#)

References

- HMGA2: A Potential Biomarker Complement to P53 for Detection of Early-stage High-grade Papillary Serous Carcinoma in Fallopian Tubes. Wei JJ, Wu J, Luan C, Yeldandi A, Lee P, Keh P, Liu J. Am J Surg Pathol. 2009 Oct 28. PMID: #19898227#