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serous tubal intraepithelial carcinoma

Sunday 15 November 2009

Definition: Thorough examination of these fallopian tubes revealed frequent association of serous tubal intraepithelial carcinoma (STIC) or tubal intraepithelial dysplasia, which usually has p53 mutations.

A recent characterization of serous tubal intraepithelial carcinoma (STIC) and of the p53 signature suggested that HG-PSC may follow a stepwise progression on cellular and molecular levels. (19898227)

Studies to find STICs are most often based on the morphology by hematoxylin and eosin (H&E) staining where diagnostic reproducibility is low.

Images

- Serous tubal intraepithelial carcinoma (STIC) in Fallopian tube. Precursor to high-grade serous carcinoma / HGSC

- Tubal epithelial dysplasia

See also

- tubal epithelial anomalies

Morphology

- high grade nuclear atypia

- architectural changes / architectural anomalies

  • loss of cellular polarity
  • nuclear tratification

- absence of cilia
- presence of mitotic figures / mitotic activity

HMGA2

In invasive carcinoma, HMGA2 overexpression is correlated with p53, indicating the role of HMGA2 in p53 mediated tumor progression. Immunoreactivity for HMGA2 may lead to a novel, useful biomarker to complement p53 in the detection of early-stage serous carcinoma. (19898227)

Open references

- Incidence of Serous Tubal Intraepithelial Carcinoma (STIC) by Algorithm Classification in Serous Ovarian Tumor Associated with PAX8 Expression in Tubal Epithelia: A Study of Single Institution in Japan. 2017. doi : 10.1097/PGP.0000000000000108

- Clinical Outcome of Isolated Serous Tubal Intraepithelial Carcinomas (STIC). 2013. doi : 10.1097/IGC.0b013e3182a80ac8

Paywall References

- HMGA2: A Potential Biomarker Complement to P53 for Detection of Early-stage High-grade Papillary Serous Carcinoma in Fallopian Tubes. Wei JJ, Wu J, Luan C, Yeldandi A, Lee P, Keh P, Liu J. Am J Surg Pathol. 2009 Oct 28. PMID: 19898227