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CDC7

MIM.603311 1p21 Entrez:8317

Thursday 12 November 2009

CDC7L1

Cell division cycle 7 is a widely expressed protein kinase implicated in cell division, cell cycle checkpoint mechanisms, and cancer progression.

Pathology

- overexpression in tumors

  • CDC7 gene is overexpressed in some tumors and transformed cell lines. (9573348)
  • Cdc7 is highly expressed in CRC and a potential therapeutic target in a subset of cancers with high p53 expression. (26208856)
  • Cdc7 immunostaining may be an independent prognostic biomarker in colorectal cancer enabling to select patients for adjuvant treatment. (26208856)

- breast carcinomas

  • Cell division cycle 7 is a replication associated protein with relationships to gene amplification and genomic instability in breast carcinomas. (19896697)

Open references

- Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer. Melling N, Muth J, Simon R, Bokemeyer C, Terracciano L, Sauter G, Izbicki JR, Marx AH. Diagn Pathol. 2015 Jul 25;10:125. doi : 10.1186/s13000-015-0360-7 PMID: 26208856

References

- Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer. Choschzick M, Lebeau A, Marx AH, Tharun L, Terracciano L, Heilenkötter U, Jaenicke F, Bokemeyer C, Simon R, Sauter G, Schwarz J. Hum Pathol. 2009 Nov 5. PMID: 19896697

- Hess, G. F.; Drong, R. F.; Weiland, K. L.; Slightom, J. L.; Sclafani, R. A.; Hollingsworth, R. E. : A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. Gene 211: 133-140, 1998. PubMed ID : 9573348