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CDC7

MIM.603311 1p21 Entrez:8317

Thursday 12 November 2009

CDC7L1

Cell division cycle 7 is a widely expressed protein kinase implicated in cell division, cell cycle checkpoint mechanisms, and cancer progression.

Pathology

- overexpression in tumors

  • CDC7 gene is overexpressed in some tumors and transformed cell lines. (9573348)
  • Cdc7 is highly expressed in CRC and a potential therapeutic target in a subset of cancers with high p53 expression. (26208856)
  • Cdc7 immunostaining may be an independent prognostic biomarker in colorectal cancer enabling to select patients for adjuvant treatment. (26208856)

- breast carcinomas

  • Cell division cycle 7 is a replication associated protein with relationships to gene amplification and genomic instability in breast carcinomas. (19896697)

Open references

- Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer. Melling N, Muth J, Simon R, Bokemeyer C, Terracciano L, Sauter G, Izbicki JR, Marx AH. Diagn Pathol. 2015 Jul 25;10:125. doi : 10.1186/s13000-015-0360-7 PMID: 26208856

References

- Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer. Choschzick M, Lebeau A, Marx AH, Tharun L, Terracciano L, Heilenk├Âtter U, Jaenicke F, Bokemeyer C, Simon R, Sauter G, Schwarz J. Hum Pathol. 2009 Nov 5. PMID: 19896697

- Hess, G. F.; Drong, R. F.; Weiland, K. L.; Slightom, J. L.; Sclafani, R. A.; Hollingsworth, R. E. : A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. Gene 211: 133-140, 1998. PubMed ID : 9573348