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ADAM28

Thursday 12 November 2009

The A disintegrin and metalloproteinases are a new gene family of proteins (ADAMs) having a metalloprotease domain with matrix metalloproteinases and play an important role in the chondrocyte development process.

Pathology

- conventional chondrosarcoma

Low-grade chondrosarcoma and enchondroma are occasionally difficult to differentiate solely by reference to clinicoradiologic and histologic findings.

Overexpression of A disintegrin and metalloproteinase 28 (ADAM28) is increased according to its histologic grade in conventional chondrosarcoma and could be one of the helpful tools in distinguishing between low-grade chondrosarcoma and enchondroma. (#19896699#)

References

- Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma. Matsuura S, Oda Y, Matono H, Izumi T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M. Hum Pathol. 2009 Nov 6. PMID: #19896699#