Home > D. Systemic pathology > Genetic and developmental anomalies > neural crest

neural crest

Monday 3 November 2003

Neural crest cells are a group of cells that migrate from the opposing epithelial folds of the closing neural tube in the back of the embryo to a number of positions inside the embryo.

These cells contribute to the development of several organs, the heart, facial skeleton, thymus, parathyroid, adrenal medulla and the whole peripheral nervous system. Neural crest cells are also needed for a normal development of the outflow region of the heart as well as for correct architecture of the large vessels connected to the heart.

Pathology

- anomalies of neural crest migration

Features

- neural crest cell motility
- neural crest cell migration

References

- Santagati F, Rijli FM. Cranial neural crest and the building of the vertebrate head. Nat Rev Neurosci. 2003 Oct;4(10):806-18. PMID: #14523380#

- Gammill LS, Bronner-Fraser M. Neural crest specification: migrating into genomics. Nat Rev Neurosci. 2003 Oct;4(10):795-805. PMID: 14523379#

- Chambers D, McGonnell IM. Neural crest: facing the facts of head development. Trends Genet. 2002 Aug;18(8):381-4. PMID: #12141999#

- Francis NJ, Landis SC. Cellular and molecular determinants of sympathetic neuron development. Annu Rev Neurosci. 1999;22:541-66. PMID: #10202548#

- Anderson DJ. Cellular and molecular biology of neural crest cell lineage determination. Trends Genet. 1997 Jul;13(7):276-80. PMID: #9242050#

- Anderson DJ. Molecular control of cell fate in the neural crest: the sympathoadrenal lineage. Annu Rev Neurosci. 1993;16:129-58. PMID: #8460888#