Monday 3 November 2003
Neural crest cells are a group of cells that migrate from the opposing epithelial folds of the closing neural tube in the back of the embryo to a number of positions inside the embryo.
These cells contribute to the development of several organs, the heart, facial skeleton, thymus, parathyroid, adrenal medulla and the whole peripheral nervous system. Neural crest cells are also needed for a normal development of the outflow region of the heart as well as for correct architecture of the large vessels connected to the heart.
neural crest cell motility
neural crest cell migration
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Gammill LS, Bronner-Fraser M. Neural crest specification: migrating into genomics. Nat Rev Neurosci. 2003 Oct;4(10):795-805. PMID: 14523379#
Francis NJ, Landis SC. Cellular and molecular determinants of sympathetic neuron development. Annu Rev Neurosci. 1999;22:541-66. PMID: 10202548