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CD23

Wednesday 28 October 2009

HUGO:FCER2

PO

See: FCER2

Roles

- CD23 is a key molecule for B-cell activation and growth. It is a low affinity IgE receptor (Fc fragment of IgE receptor, FCERs).
- CD23 is a type C lectin that can be secreted.
- After physiologic germinal cell development, the follicular dendritic cell meshwork expands and follicular dendritic cells in the light zone of the germinal center become CD23 positive.
- CD23 acts as a B cell growth and activation factor, promoting differentiation into plasma cells.
- CD23 regulates IgE synthesis through CD21 and IgE binding and mediates IgE related immune responses.
- CD21, CD23 and CD35 are dendritic cell markers.

Expression

- follicular dendritic cells
- Activated mature B cells expressing IgM or IgD (particularly mantle cells)
- activated monocytes / macrophages
- T cell subsets
- platelets
- eosinophils
- Langerhans cells,
- intestinal epithelium (encodes IgE receptor, Gastroenterology 2005;129:928)

Flow cytometry

- CD23 shows variability in flow cytometry expression between specimens from same patient.

Diagnosis

- CD21, CD23 and CD35 are dendritic cell markers.
- CD23 differentiate SLL/CLL (CD23+) vs. mantle cell lymphoma or MALT lymphoma (CD23-)
- CD23 is a B cell marker, particularly for SLL/CLL, mediastinal large B cell lymphoma and lymphoplasmacytic lymphoma.
- CD23 distinguishes nodal mantle cell lymphoma from follicular lymphoma by identifying a disrupted follicular dendritic cell pattern (Int J Surg Pathol 2005;13:73).