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hybrid tumor oncocytoma-chromophobe renal cell carcinoma

Friday 23 October 2009

Hybrid renal cell carcinoma (HRCN) is a rare type of renal tumor with characteristic pathologic features, including oncocytic and chromophobe cellular content.

Hybrid renal cell carcinoma (HRCN) shows more favorable prognosis than renal cell carcinoma. The early-stage tumors show favorable outcome, and postoperative regular clinical and radiological follow-up is adequate in most cases.

HT are characterized by the association of both oncocytes and chromophobe cells (CRCC) within the same tumour.

They have been described in patients with oncocytosis and Birt-Hogg-Dube syndrome.

In a series of patients with sporadic RO and CRCC, 10% of the tumours had hybrid morphological features, as described in oncocytosis and Birt-Hogg-Dube syndrome (19154497).

See also

- renal tumors

References

- A rare type of renal cell carcinoma in a girl: hybrid renal cell carcinoma. Kesik V, Yalçin B, Akçören Z, Senocak ME, Talim B, Büyükpamukçu M. Pediatr Hematol Oncol. 2010 Apr;27(3):228-32. PMID: 20367266

- Hybrid tumour ’oncocytoma-chromophobe renal cell carcinoma’ of the kidney: a report of seven sporadic cases. Delongchamps NB, Galmiche L, Eiss D, Rouach Y, Vogt B, Timsit MO, Vieillefond A, Méjean A. BJU Int. 2009 May;103(10):1381-4. PMID: 19154497

- Cytologic and histologic findings in multiple renal hybrid oncocytic tumors in a patient with Birt-Hogg-Dubé syndrome: a case report. Adley BP, Schafernak KT, Yeldandi AV, Yang XJ, Nayar R. Acta Cytol. 2006 Sep-Oct;50(5):584-8. PMID: 17017453

- Hybrid chromophobe renal cell neoplasm. Mai KT, Dhamanaskar P, Belanger E, Stinson WA. Pathol Res Pract. 2005;201(5):385-9. PMID: 16047948

- Cytologic and histologic findings in multiple renal hybrid oncocytic tumors in a patient with Birt-Hogg-Dubé syndrome: a case report. Adley BP, Schafernak KT, Yeldandi AV, Yang XJ, Nayar R. Acta Cytol. 2006 Sep-Oct;50(5):584-8. PMID: 17017453

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