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CCND2

12p13 HGNC:1583 MIM.123833

Wednesday 21 October 2009

The cytogenetic and diagnostic hallmark of mantle cell lymphoma (MCL) is translocation t(11;14)(q13;q32), resulting in overexpression of cyclin D1.

There are rare cyclin D1-negative cases of MCL overexpressing cyclin D2. Anti-cyclin D1 antibodies with low specificity can bind both cyclin D1 and cyclin D2, thus providing false cyclin D1-positive signals in immunohistochemical analysis. (19783727)

References

- Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected. Stefancikova L, Moulis M, Fabian P, Falkova I, Vasova I, Kren L, Macak J, Smardova J. J Clin Pathol. 2009 Oct;62(10):948-50. PMID: 19783727