Home > G. Tumoral pathology > vascular tumors

vascular tumors

Thursday 30 October 2003

Digital cases

- UI:703 - Cutaneous glomus tumor.
- JRC:10992 : Cutaneous glomus tumor.

Classification

- vascular malformations
- benign vascular tumors

  • congenital hemangiomas (RICH and NICH)
  • juvenile hemangioma (infantile hemangioma)
  • targetoid hemosiderotic hemangioma
  • epithelioid hemangioma

- hemangioendotheliomas

  • spindle cell hemangioendothelioma
  • kaposiform hemangioendothelioma
  • epithelioid hemangioendothelioma

- lymphatic anomalies

  • lymphatic malformations
  • lymphatic tumors
  • lymphangioendotheliomatosis

- malignant vascular tumors

  • angiosarcoma
  • Kaposi sarcoma

- hemangiopericytic tumors

  • infantile hemangiopericytoma

- glomus tumors

  • glomangioma

According to the localization

- bone vascular tumors (osseous vascular tumors)
- cutaneous vascular tumors
- hepatic vascular tumors
- muscular vascular tumors
- soft tissue vascular tumors
- cardiac vascular tumors

Vascular tumors with lobular architecture

- lobular capillary hemangioma
- pyogenic granuloma
- infantile hemangioma
- some congenital hemangiomas (RICH and NICH)

β-Adrenergic receptor expression in vascular tumors (#22743651#)

Propranolol has recently emerged as an effective therapy for infantile hemangiomas causing regression.

The β-adrenergic receptor (AR) antagonist is thought to cause vasoconstriction by its effect on nitric oxide, block angiogenesis by its effect on vascular endothelial growth factor (VEGF), and induce apoptosis.

The expression of β2-AR (B2-AR) and its phosphorylated form (B2-ARP) have been identified in a case of infantile hemangioma that responded to propranolol treatment.

Although immunohistochemical expression of the receptors does not necessarily indicate that similar pathways of responsiveness to β-blockade are present, it does raises the possibility that β-blockade could potentially affect apoptosis and decrease responsiveness to VEGF.

See also

- cutaneous tumors
- vascular malformations

Reviews

- Vikkula M, Boon LM, Mulliken JB, Olsen BR. Molecular basis of vascular anomalies. Trends Cardiovasc Med. 1998 Oct;8(7):281-92. PMID: #14987552#

References

- β-Adrenergic receptor expression in vascular tumors. Chisholm KM, Chang KW, Truong MT, Kwok S, West RB, Heerema-McKenney AE. Mod Pathol. 2012 Jun 29. PMID: #22743651#

Portfolio

  • Nasal juvenile angiofibroma
  • Nasal juvenile angiofibroma
  • Nasal juvenile angiofibroma
  • Lobular capillary hemangioma
  • Lingual lymphangioma
  • Lobular capillary hemangioma
  • Lobular capillary hemangioma
  • Lobular capillary hemangioma
  • Juvenile angiofibroma
  • Juvenile angiofibroma
  • Juvenile angiofibroma
  • Glomangioma
  • Infantile hemangioma