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nitrofurantoin

Monday 15 June 2009

Nitrofurantoin is used to treat urinary tract infections. The hepatic injury can manifest as self-limited acute hepatitis, chronic hepatitis, and rarely as hepatic failure.

Chronic hepatitis can be indistinguishable from de novo AIH and is often associated with ANA and SMA.

Discontinuation of the drug generally leads to clinical and biochemical improvement.

In some cases, the disease may progress despite drug withdrawal. In contrast to minocycline, significant fibrosis and cirrhosis can occur.