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MMPs

Wednesday 29 October 2003

Increased expression of matrix metalloproteinases (MMPs) is associated with nearly every tumor type. Although many studies have shown that MMPs can promote malignancy, recent evidence has revealed that MMPs can play a causative role also in the earliest stages of cancer development.

MMPs not only compromise cell-cell and cell-substratum adhesion processes that impact genomic surveillance mechanisms but also act directly on molecules at the cell surface to stimulate physiological processes that cause genetic alterations.

Members

MMP1 MMP2 MMP3 MMP4 MMP5 MMP6 MMP7 MMP8 MMP9 MMP10
MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP18 MMP19 MMP20
MMP21 MMP22 MMP23 MMP24 MMP25 MMP26 MMP27 MMP28

Pathology

- MMP3 (MIM.185250) variants in coronary heart disease susceptibility
- MMPs in cancer and metastasis
- MMPs in HIV infection

  • Imbalance between matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of MMPs (TIMPs) might contribute to HIV-associated pathology by inducing remodelling of the extracellular matrix. (18029231)
  • Antiretroviral drugs, particularly HIV protease inhibitors (PIs), and compounds with anti-inflammatory properties, such as statins, natural omega-3 fatty acids and tetracyclines, which inhibit MMP function, might represent useful therapeutic approaches to mitigate potential MMP-related damage during HIV infection. (18029231)

References

- Mastroianni CM, Liuzzi GM. Matrix metalloproteinase dysregulation in HIV infection: implications for therapeutic strategies. Trends Mol Med. 2007 Oct 26; PMID: 18029231

- Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 2007 Mar;8(3):221-33. PMID: 17318226

- Radisky DC, Bissell MJ. Matrix metalloproteinase-induced genomic instability. Curr Opin Genet Dev. 2006 Feb;16(1):45-50. PMID: 16377172

- Ortega N, Behonick DJ, Werb Z. Matrix remodeling during endochondral ossification. Trends Cell Biol. 2004 Feb;14(2):86-93. PMID: 15102440

- Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol. 2003 Jul;200(4):448-64. PMID: 12845612

- Overall CM, Lopez-Otin C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002 Sep;2(9):657-72. PMID: 12209155

- Rhee JS, Coussens LM. RECKing MMP function: implications for cancer development. Trends Cell Biol. 2002 May;12(5):209-11. PMID: 12062160

- Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol. 2001 Nov;11(11):S37-43. PMID: 11684441