Tuesday 2 June 2009
AGTR1 code for the angiotensin II receptor type I.
AGTR1 is overexpressed in 10 to 20 percent of breast cancer cases.
overexpression in tumors
AGTR1 is highly overexpressed in many cases of breast cancer, but that it’s only found in excess in tumors that lacked ERBB2, or HER2, and that expressed the estrogen receptor, ER-positive.
Tests on mice with tumors overexpressing AGTR1 found that the blood pressure drug losartan shrank the tumors by 30 percent within eight weeks of treatment. [http://www.pnas.org/content/early/2009/06/01/0900351106.abstract]