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Tuesday 2 June 2009

Ixabepilone, a semi-synthetic analog of the natural product epothilone B, is a non-taxane microtubule-stabilizing agent active against cancers insensitive to paclitaxel.

Ixabepilone (INN; also known as azaepothilone B, codenamed BMS-247550) is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It is produced by Sorangium cellulosum.

Ixabepilone acts to stabilize microtubules.


Ixabepilone, in combination with capecitabine, has demonstrated effectiveness in the treatment of metastatic or locally advanced breast cancer in patients after failure of an anthracycline and a taxane.

It has been investigated for use in treatment of non-Hodgkin’s lymphoma.


- Wikipedia