Home > E. Pathology by systems > Urinary system > Kidneys > renal cell tumors

renal cell tumors

Tuesday 26 May 2009

Types

- papillary adenoma
- renal oncocytoma
- renal cell carcinomas

  • clear cell renal cell carcinoma
  • papillary renal cell carcinoma
  • chromophobe renal cell carcinoma
  • Bellini collecting ducts renal cell carcinoma
  • renal medullary carcinoma
  • TFE3-associated renal cell carcinoma (Xp11 translocation-associated renal cell carcinoma)
  • TFEB-associated renal cell carcinoma
    • TFEB-associated HMB45+ epithelioid renal tumor

Immunochemistry

Onc: Oncocytoma
ClC-RCC, EosinCytoplasm
Chromophobe Carcinoma, Eosinophilic Variant
EAML: Epithelioid Angiomyolipoma
PRCC2: Papillary RenalCell Carcinoma (Pap RCC), Type 2
TRCC: Translocation Carcinoma t(6:11)t(6;11)
CDC: Collecting DuctCarcinoma
MC: Medullary Carcinoma
TCC: TubulocysticCarcinoma
TMSCC: Tubular Mucinous Spindle Cell Carcinoma

Antibody Onc. ClC-RCC ChC-RCC EAML PRCC2 TRCC CDC MC TCC TMSCC
CAM 5.2 pos pos pos neg pos neg pos pos pos pos
AE1/AE3 pos pos pos neg pos neg pos pos pos pos
Vimentin neg pos neg neg pos pos pos pos - pos
EMA pos pos pos neg pos neg pos pos - pos
CD10 pos/neg pos pos/neg neg pos pos pos/neg - pos pos/neg
RCC Ma neg pos neg neg pos/neg - - - - neg
CK7 “patchy” neg pos neg pos neg pos pos pos pos
CK20 neg neg neg neg neg neg neg neg neg neg
CK19 neg neg neg neg neg pos/neg pos pos pos/neg pos 34BE12 neg neg neg neg pos/neg neg pos/neg neg pos/neg pos/neg
AMACR neg neg neg - pos pos neg - pos pos
Parvalbumin pos neg pos - neg - - - pos - S100A1 pos pos neg - pos - - - - -
C-kit pos neg pos neg pos/neg - pos/neg - - neg

E-cadherin pos neg pos - pos/neg pos pos - - -
Kid sp cad pos neg pos - neg neg neg neg neg neg
Caveolin-1 neg - pos - - - - - - -
Cathepsin K neg neg neg - neg pos - - - -
PAX-2 pos pos neg - pos/neg neg neg - pos pos/neg
TFE3 neg neg pos - neg pos - - - -
TFEB neg neg - - neg neg - - - -
UEA-1 neg neg - - pos/neg - pos - pos -
HMB 45 neg neg neg pos neg neg neg neg neg neg
Melan A neg neg neg pos neg neg neg neg neg neg
Coll iron neg neg pos - neg neg neg neg neg neg

Links

- Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features by Dako

References

- The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, Hes O, Moch H, Montironi R, Tickoo SK, Zhou M, Argani P; The ISUP Renal Tumor Panel. Am J Surg Pathol. 2013 Oct;37(10):1469-1489. PMID: 24025519

- Molecular approaches to classify adult renal epithelial neoplasms. Maj M, Wagner L. Expert Rev Mol Diagn. 2011 Nov;11(8):803-6. PMID: 22022942

- Molecular classification of adult renal epithelial neoplasms using microRNA expression and virtual karyotyping. Powers MP, Alvarez K, Kim HJ, Monzon FA. Diagn Mol Pathol. 2011 Jun;20(2):63-70. PMID: 21532496

- Virtual-Karyotyping With SNP Microarrays in Morphologically Challenging Renal Cell Neoplasms: A Practical and Useful Diagnostic Modality. Kim HJ, Shen SS, Ayala AG, Ro JY, Truong LD, Alvarez K, Bridge JA, Gatalica Z, Hagenkord JM, Gonzalez-Berjon JM, Monzon FA. Am J Surg Pathol. 2009 May 20. PMID: 19461508

Portfolio

  • Renal oncocytoma
  • Renal oncocytoma