Home > E. Pathology by systems > Urinary system > Kidneys > renal cell tumors
renal cell tumors
Tuesday 26 May 2009
Types
papillary adenoma renal oncocytoma renal cell carcinomas
- clear cell renal cell carcinoma
- papillary renal cell carcinoma
- chromophobe renal cell carcinoma
- Bellini collecting ducts renal cell carcinoma
- renal medullary carcinoma
- TFE3-associated renal cell carcinoma (Xp11 translocation-associated renal cell carcinoma)
- TFEB-associated renal cell carcinoma
- TFEB-associated HMB45+ epithelioid renal tumor
Immunochemistry
Onc: Oncocytoma
ClC-RCC, EosinCytoplasm
Chromophobe Carcinoma, Eosinophilic Variant
EAML: Epithelioid Angiomyolipoma
PRCC2: Papillary RenalCell Carcinoma (Pap RCC), Type 2
TRCC: Translocation Carcinoma t(6:11)t(6;11)
CDC: Collecting DuctCarcinoma
MC: Medullary Carcinoma
TCC: TubulocysticCarcinoma
TMSCC: Tubular Mucinous Spindle Cell Carcinoma
| Antibody | Onc. | ClC-RCC | ChC-RCC | EAML | PRCC2 | TRCC | CDC | MC | TCC | TMSCC | |||||||||||
| CAM 5.2 | pos | pos | pos | neg | pos | neg | pos | pos | pos | pos | |||||||||||
| AE1/AE3 | pos | pos | pos | neg | pos | neg | pos | pos | pos | pos | |||||||||||
| Vimentin | neg | pos | neg | neg | pos | pos | pos | pos | - | pos | |||||||||||
| EMA | pos | pos | pos | neg | pos | neg | pos | pos | - | pos | |||||||||||
| CD10 | pos/neg | pos | pos/neg | neg | pos | pos | pos/neg | - | pos | pos/neg | |||||||||||
| RCC Ma | neg | pos | neg | neg | pos/neg | - | - | - | - | neg | |||||||||||
| CK7 | “patchy” | neg | pos | neg | pos | neg | pos | pos | pos | pos | |||||||||||
| CK20 | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | |||||||||||
| CK19 | neg | neg | neg | neg | neg | pos/neg | pos | pos | pos/neg | pos | 34BE12 | neg | neg | neg | neg | pos/neg | neg | pos/neg | neg | pos/neg | pos/neg |
| AMACR | neg | neg | neg | - | pos | pos | neg | - | pos | pos | |||||||||||
| Parvalbumin | pos | neg | pos | - | neg | - | - | - | pos | - | S100A1 | pos | pos | neg | - | pos | - | - | - | - | - |
| C-kit | pos | neg | pos | neg | pos/neg | - | pos/neg | - | - | neg |
E-cadherin pos neg pos - pos/neg pos pos - - -
Kid sp cad pos neg pos - neg neg neg neg neg neg
Caveolin-1 neg - pos - - - - - - -
Cathepsin K neg neg neg - neg pos - - - -
PAX-2 pos pos neg - pos/neg neg neg - pos pos/neg
TFE3 neg neg pos - neg pos - - - -
TFEB neg neg - - neg neg - - - -
UEA-1 neg neg - - pos/neg - pos - pos -
HMB 45 neg neg neg pos neg neg neg neg neg neg
Melan A neg neg neg pos neg neg neg neg neg neg
Coll iron neg neg pos - neg neg neg neg neg neg
Links
Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features by Dako
References
Molecular approaches to classify adult renal epithelial neoplasms. Maj M, Wagner L. Expert Rev Mol Diagn. 2011 Nov;11(8):803-6. PMID: #22022942#
Molecular classification of adult renal epithelial neoplasms using microRNA expression and virtual karyotyping. Powers MP, Alvarez K, Kim HJ, Monzon FA. Diagn Mol Pathol. 2011 Jun;20(2):63-70. PMID: #21532496#
Virtual-Karyotyping With SNP Microarrays in Morphologically Challenging Renal Cell Neoplasms: A Practical and Useful Diagnostic Modality. Kim HJ, Shen SS, Ayala AG, Ro JY, Truong LD, Alvarez K, Bridge JA, Gatalica Z, Hagenkord JM, Gonzalez-Berjon JM, Monzon FA. Am J Surg Pathol. 2009 May 20. PMID: #19461508#
