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metastasis

Wednesday 29 October 2003

cancer metastasis, tumoral metastasis

Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare tumour cells that overcame stringent physiological barriers as they separated from their original environment and developmental fate.

This phenomenon brings into focus long-standing questions about the stage at which cancer cells acquire metastatic abilities, the relationship of metastatic cells to their tumour of origin, the basis for metastatic tissue tropism, the nature of metastasis predisposition factors and, importantly, the identity of genes that mediate these processes.

Types

- lymphatic dissemination

  • nodal metastasis
  • carcinomatous lymphangitis

- visceral metastasis

  • pulmonary metastasis
  • hepatic metastasis
  • cerebral metastasis

- osseous metastasis (bone metastasis)
- placental metastasis

Videos

- "Identification of metastasis of unknown origin using Cancer Type ID", Jean-Marie Bruey, BioTheranostics, San Diego, CA, USA

< iframe src="http://player.vimeo.com/video/49872638?badge=0" width="500" height="281" frameborder="0" webkitAllowFullScreen mozallowfullscreen allowFullScreen> < /iframe> < p> < a href="http://vimeo.com/49872638">1-6 JEAN-MARIE BRUEY - IDENTIFICATION OF METASTASIS < /a> from < a href="http://vimeo.com/biopathology">Biopathology < /a> on < a href="http://vimeo.com">Vimeo < /a>. < /p>

See also

- circulating tumoral cells
- metastasis of unknow origin

References

- Yilmaz M, Christofori G, Lehembre F. Distinct mechanisms of tumor invasion and metastasis. Trends Mol Med. 2007 Dec;13(12):535-41. PMID: 17981506

- Sahai E. Illuminating the metastatic process. Nat Rev Cancer. 2007 Oct;7(10):737-49. PMID: 17891189

- Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet. 2007 May;8(5):341-52. PMID: 17440531

- Crawford NP, Hunter KW. New perspectives on hereditary influences in metastatic progression. Trends Genet. 2006 Oct;22(10):555-61. PMID: 16889869

- Mocellin S, Keilholz U, Rossi CR, Nitti D. Circulating tumor cells: the ’leukemic phase’ of solid cancers. Trends Mol Med. 2006 Feb 16; PMID: 16488189

- Bogenrieder T, Herlyn M. Axis of evil: molecular mechanisms of cancer metastasis. Oncogene. 2003 Sep 29;22(42):6524-36. PMID: 14528277

- Townson JL, Naumov GN, Chambers AF. The role of apoptosis in tumor progression and metastasis. Curr Mol Med. 2003 Nov;3(7):631-42. PMID: 14601637

- Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med. 2003 Nov;3(7):659-71. PMID: 14601640

- Eccles SA. Targeting key steps in metastatic tumour progression. Curr Opin Genet Dev. 2005 Feb;15(1):77-86. PMID: 15661537

- Roodman GD. Mechanisms of bone metastasis. N Engl J Med. 2004 Apr 15;350(16):1655-64. PMID: 15084698

- Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer. 2004 Jun;4(6):448-56. PMID: 15170447

- Fidler IJ. The pathogenesis of cancer metastasis: the ’seed and soil’ hypothesis revisited. Nat Rev Cancer. 2003 Jun;3(6):453-8. PMID: 12778135

- Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H (September 2008). "Seeding and propagation of untransformed mouse mammary cells in the lung". Science (New York, N.Y.) 321 (5897): 1841–4. doi : 18755941" target="_blank">10.1126/science.1161621. PMID 18755941

- Klein CA (September 2008). "Cancer. The metastasis cascade". Science (New York, N.Y.) 321 (5897): 1785–7. doi : 18818347" target="_blank">10.1126/science.1164853. PMID 18818347

- Chiang AC, Massagué J (December 2008). "Molecular basis of metastasis". The New England Journal of Medicine 359 (26): 2814–23. PMID 19109576.

- Kumar, Vinay; Abbas, Abul K; Fausto, Nelson; Robbins, Stanley L; Cotran, Ramzi S (2005). Robbins and Cotran pathologic basis of disease (7th ed.). Philadelphia: Elsevier Saunders. ISBN 978-0-7216-0187-8.

- "Metastatic Cancer: Questions and Answers". National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Sites-Types/metastatic. Retrieved 2008-08-28.

- Robert Weinberg, The Biology of Cancer, cited in Basics: A mutinous group of cells on a greedy, destructive task, by Natalie Angier, New York Times, April 3, 2007

- Bacac, M; Stamenkovic, I (February 2008). "Metastatic cancer cell". Annual Review of Pathology.

- Yoshida BA, Sokoloff MM, Welch DR, Rinker-Schaeffer CW (Nov 2000). "Metastasis-suppressor genes: a review and perspective on an emerging field". J Natl Cancer Inst. 92 (21): 1717–30.

- Weidner N, Semple JP, Welch WR, Folkman J (Jan 1991). "Tumor angiogenesis and metastasis—correlation in invasive breast carcinoma". N Engl J Med. 324 (1): 1–8. PMID 1701519.

- Briasoulis E, Pavlidis N (1997). "Cancer of Unknown Primary Origin". Oncologist 2 (3): 142–152. PMID 10388044.

- Poste G, Fidler IJ (January 1980). "The pathogenesis of cancer metastasis". Nature 283 (5743): 139–46. doi : 6985715" target="_blank">10.1038/283139a0. PMID 6985715

- Ramaswamy S, Ross KN, Lander ES, Golub TR (January 2003). "A molecular signature of metastasis in primary solid tumors". Nature Genetics 33 (1): 49–54. doi : 12469122" target="_blank">10.1038/ng1060. PMID 12469122

- van ’t Veer LJ, Dai H, van de Vijver MJ, et al. (January 2002). "Gene expression profiling predicts clinical outcome of breast cancer". Nature 415 (6871): 530–6. doi : 11823860" target="_blank">10.1038/415530a. PMID 11823860

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