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epithelioid angiosarcoma

Thursday 2 September 2010

Digital slides

- JRC:2967 : Duodenal epithelioid angiosarcoma

Case records

- http://www.pathology.med.ohio-state.edu/ext/COTW/cases/1-50/case41.aspx

Localization

- cutaneous epithelioid angiosarcoma
- vesical epithelioid angiosarcoma

Microscopically

Epithelioid angiosarcoma may have a broad morphological spectrum, raising interpretive challenges on microscopy.

- packed polygonal cells with focal evidence of endothelial differentiation
- +/- syncytial growth of large cells with clear nuclei and prominent nucleoli,
- +/- discohesive plasmacytoid polygonal cells with abundant bright eosinophilic cytoplasm
- +/- sheets of clear cells with coarse granular cytoplasm
- trabecular and cord arrangement of tumor cells
- +/- pseudoglandular appearance owing to clear cell tubular arrangement with open lumina

Differential diagnosis

- lymphoma
- melanoma
- lymphoepithelioma-like carcinoma
- adnexal carcinoma
- neuroendocrine carcinoma

Immunochemistry

- positivity for CD31 and CD34;
- no immunoreactivity for other antigens including cytokeratins, S100 protein, melanocytic antigens, leukocyte common antigen, and desmin.

Therapeutics

- local excision
- chemotherapy
- radiotherapy

Variants

- epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma (17574948)

See also

- angiosarcomas

References

- Epithelioid angiosarcoma of the skin: a study of 18 cases with emphasis on its clinicopathologic spectrum and unusual morphologic features. Bacchi CE, Silva TR, Zambrano E, Plaza J, Suster S, Luzar B, Lamovec J, Pizzolitto S, Falconieri G. Am J Surg Pathol. 2010 Sep;34(9):1334-43. PMID: 20697249

- Epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma: a case report and literature review. Lee FY, Wen MC, Wang J. Hum Pathol. 2007 Jul;38(7):1096-101. PMID: 17574948