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plexiform cellular schwannoma

Thursday 7 May 2009

Plexiform nerve sheath tumor of childhood had been previously designated a form of malignant peripheral nerve sheath tumor (MPNST). These tumors are in fact benign plexiform cellular schwannomas.

The behavior is that of a benign tumor, although its often rapid growth, hypercellularity and increased mitotic activity, sometimes locally aggressive behavior, and difficulties encountered in obtaining tumor-free margins are unsettling to pathologist and clinician alike. These features may lead to a misdiagnosis of malignancy, which could result in harmful overtreatment. (14508393)

See also

- plexiform schwannoma

  • plexiform tumors


- Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. Woodruff JM, Scheithauer BW, Kurtkaya-Yapicier O, Raffel C, Amr SS, LaQuaglia MP, Antonescu CR. Am J Surg Pathol. 2003 Oct;27(10):1321-9. PMID: 14508393