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spinocerebellar degeneration

Tuesday 14 April 2009

Spinocerebellar degenerations affect, to a variable extent, the cerebellar cortex, spinal cord, peripheral nerves, and other regions of the neuraxis.

The clinical spectrum includes cerebellar and sensory ataxia, spasticity, and sensorimotor peripheral neuropathy. This is a clinically heterogeneous group of illnesses that include several distinct diseases; these can be distinguished on the basis of their patterns of inheritance, age at onset, and pattern of signs and symptoms.

Degeneration of neurons, without distinctive histopathologic changes, occurs in the affected areas and is associated with mild gliosis. Genetic analysis continues to redefine and subclassify these illnesses.

Examples

- spinocerebellar ataxias