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BCOR

HGNC:20893 Xp11.4 MIM.300485

Saturday 1 January 2011

BCL6 corepressor; FLJ20285, KIAA1575

Pathology

- A new subtype of bone sarcoma is defined by BCOR-CCNB3 gene fusion. (22387997)

  • CCNB3 immunohistochemistry is a powerful diagnostic marker for this subgroup of sarcoma and that overexpression of BCOR-CCNB3 or of truncated CCNB3 activates S phase in NIH3T3 cells.
  • The intrachromosomal X-chromosome fusion represents a new subtype of bone sarcoma caused by a newly identified gene fusion mechanism.

References

- A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion. Pierron G, Tirode F, Lucchesi C, Reynaud S, Ballet S, Cohen-Gogo S, Perrin V, Coindre JM, Delattre O. Nat Genet. 2012 Mar 4. PMID: 22387997