Monday 23 March 2009
When sufficient energy is stored in adipose tissue and the individual is well fed, afferent adiposity signals (insulin, leptin, ghrelin) are delivered to the central neuronal processing units, in the hypothalamus. Here the adiposity signals inhibit anabolic circuits and activate catabolic circuits.
The effector arms of these central circuits then impact on energy balance by inhibiting food intake and promoting energy expenditure. This in turn reduces the energy stores and the adiposity signals are obtunded.
Conversely, when energy stores are low, the available anabolic circuits take over at the expense of catabolic circuits to generate energy stores in the form of adipose tissue, thus generating an equilibrium.