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type 2 mixed cryoglobulinemia

Thursday 19 March 2009

Type II cryoglobulins are mixed polyclonal and monoclonal immunoglobulins, frequently found in excess of 1 mg/mL. They may begin to precipitate within hours of refrigeration and are usually apparent by the next day.

Etiology (Examples)

- chronic HCV infection
- drugs

Case studies



- Cotrimoxazole induced mixed type II cryoglobulinemia. Leclercq P, Frippiat F, Lambermont B. Eur J Intern Med. 2008 Jun;19(4):303-4. PMID: 18471685