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T-cell and B-cell PTLDs association

Tuesday 28 October 2008

Posttransplant lymphoproliferative disorders (PTLDs) may occur as a complication of immunosuppression in patients who have received solid organ or bone marrow allografts.

Most PTLDs are of B-cell lineage, whereas T-cell proliferations are rare.

The majority of B-cell lesions are associated with Epstein-Barr virus infection.

References

- Metachronous EBV-associated B-cell and T-cell posttransplant lymphoproliferative disorders in a heart transplant recipient. Morovic A, Jaffe ES, Raffeld M, Schrager JA. Am J Surg Pathol. 2009 Jan;33(1):149-54. PMID: 18941401