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renal C4d deposits

Thursday 16 October 2008, by JA

Diffuse C4d deposition in peritubular capillaries is a well-recognized marker of antibody-mediated rejection.

References

- Batal I, Girnita A, Zeevi A, Saab BA, Stockhausen S, Shapiro R, Basu A, Tan H, Morgan C, Randhawa P. Clinical significance of the distribution of C4d deposits in different anatomic compartments of the allograft kidney. Mod Pathol. 2008 Sep 26. PMID: #18820671#

- Poduval RD, Kadambi PV, Josephson MA, Cohn RA, Harland RC, Javaid B, Huo D, Manaligod JR, Thistlethwaite JR, Meehan SM. Implications of immunohistochemical detection of C4d along peritubular capillaries in late acute renal allograft rejection. Transplantation. 2005 Jan 27;79(2):228-35. PMID: #15665772#

- Baldwin WM 3rd, Kasper EK, Zachary AA, Wasowska BA, Rodriguez ER. Beyond C4d: other complement-related diagnostic approaches to antibody-mediated rejection. Am J Transplant. 2004 Mar;4(3):311-8. PMID: #14961982#

- Nickeleit V, Mihatsch MJ. Kidney transplants, antibodies and rejection: is C4d a magic marker? Nephrol Dial Transplant. 2003 Nov;18(11):2232-9. PMID: #14551348#

- Feucht HE. Complement C4d in graft capillaries — the missing link in the recognition of humoral alloreactivity. Am J Transplant. 2003 Jun;3(6):646-52. PMID: #12780555#

- Mauiyyedi S, Colvin RB. Humoral rejection in kidney transplantation: new concepts in diagnosis and treatment. Curr Opin Nephrol Hypertens. 2002 Nov;11(6):609-18. PMID: #12394606#

- Watschinger B, Pascual M. Capillary C4d deposition as a marker of humoral immunity in renal allograft rejection. J Am Soc Nephrol. 2002 Sep;13(9):2420-3. PMID: #12191988#

- Platt JL. C4d and the fate of organ allografts. J Am Soc Nephrol. 2002 Sep;13(9):2417-9. PMID: #12191987#

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