Tuesday 30 September 2008
Shown to inhibit p53 transactivation activity and decrease the p53 proapoptotic response, the inhibition of YEATS4 results in p53 stabilization and activation.
YEATS4 is a transcription factor amplified in human gliomas.
YEATS4 (GAS41) as a novel oncogene important in the pathogenesis of WDLPS/DDLPS (well-differentiared liposarcoma/dedifferentiated liposarcoma).
The functional impairment of the p53 pathway plays a crucial role in WDLPS/DDLPS oncogenesis. MDM2 antagonist, Nutlin 3A, induced cell cycle arrest and apoptosis in WDLPS or DDLPS cell lines. Moreover, MDM2 antagonist, Nutlin 3A causes tumor shrinkage in MDM2 amplified sarcoma xenografts in nude mice. The frequent amplification and overexpression of YEATS4 in WDLPS/DDLPS make this gene a potential new target for the development of therapeutic strategies activating the p53 pathway.