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NUP214/ABL1

NUP214/ABL1 fusion gene

Friday 29 August 2008

CAN/Nup214 is an FXFG repeat-containing protein involved in myeloid leukemia in humans. It a component of the vertebrate nuclear pore complex (NPC), a 125-megadalton multiprotein assembly that mediates nucleocytoplasmic transport.

Pathology

- NUP214/ABL1 fusion gene in T-cell acute lymphoblastic leukemia (##15361874#)

References

- Graux, C.; Cools, J.; Melotte, C.; Quentmeier, H.; Ferrando, A.; Levine, R.; Vermeesch, J. R.; Stul, M.; Dutta, B.; Boeckx, N.; Bosly, A.; Heimann, P.; and 12 others : Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nature Genet. 36: 1084-1089, 2004. PubMed ID : #15361874#

- von Lindern, M.; Poustka, A.; Lehrach, H.; Grosveld, G. : The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34. Molec. Cell. Biol. 10: 4016-4026, 1990. PubMed ID : 2370860