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lanosterol - Humpath.com - Human pathology

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lanosterol

Monday 21 July 2008

Definition: Lanosterol is a tetracyclic triterpenoid, which is the compound from which all steroids are derived.

Elaboration of lanosterol under enzyme catalysis leads to the core structure of steroids (lanosterol synthesis pathway).

14-Demethylation of lanosterol by CYP51 eventually yields cholesterol.

Biosynthesis

- Two molecules of farnesyl pyrophosphate (FPP) condense with reduction by NADPH to form squalene.
- Squalene is oxidized to 2,3-oxidosqualene (squalene epoxide).
- 2,3-Oxidosqualene is converted to a protosterol cation and finally to lanosterol.

See also

- terpenoid (isoprenoid)

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