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Sunday 29 June 2008

FADH2 is an energy-carrying molecule. The reduced coenzyme can be used as a substrate for oxidative phosphorylation in the mitochondria.

FADH2 is reoxidized to FAD , which makes it possible to produce two moles of the universal energy carrier ATP. The primary sources of reduced FAD in eukaryotic metabolism are the citric acid cycle (Krebs cycle) and the fatty acid beta oxidation pathway.

In the citric acid cycle, FAD is a prosthetic group in the enzyme succinate dehydrogenase that oxidizes succinate to fumarate, whereas in beta oxidation of fatty acids, it serves as a coenzyme in the reaction of acyl CoA dehydrogenase.

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