Humpath.com - Human pathology

Home > G. Tumoral pathology > localized neurofibroma

localized neurofibroma

Thursday 26 June 2008

Synopsis

- 90% sporadic, 10% in the setting of neurofibromatosis 1 (NF1)
- most develop between 20-30 years

- in a major nerve :

  • fusiform expansion
  • confined by the epineurium

- in a small nerve :

  • extension in soft tissues
  • circumscribed but not encapsulated

Microscopical synopsis

- interlacing bundles of cells with ovoid-to-spindle, often curved, nuclei
- collagen fibres and myxoid matrix
- roppey collagen bundles

See also

- neurofibromas

  • plexiform neurofibroma
  • diffuse neurofibroma
  • pigmented neurofibroma
  • neurofibroma with malignant transformation (neurofibrosarcoma)

Portfolio