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monosomy 7

Monday 19 May 2008

Monosomy 7 has been described in myelodysplastic syndromes and acute myeloid or lymphoblastic leukemias, as well as in several benign or malignant solid tumors. It is not usual in adipose tissue tumors.


- myelodysplastic syndrome (MDS or myelodysplasia)

  • Myelodysplastic syndrome (MDS) is a clonal hematopoietic disorder that often results in progression to acute myeloid leukemia (AML), particularly when additional genetic abnormalities are present, such as monosomy 7.

- spindle cell liposarcoma without 12q amplification (18617058)

See also

- tumoral monosomies


- Italiano A, Chambonniere ML, Attias R, Chibon F, Coindre JM, Pedeutour F. Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas. Cancer Genet Cytogenet. 2008 Jul 15;184(2):99-104. PMID: 18617058

- Parker TM, Klaassen RJ, Johnston DL. Spontaneous remission of myelodysplastic syndrome with monosomy 7 in a young boy. Cancer Genet Cytogenet. 2008 Apr 15;182(2):122-5. PMID: 18406874