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topoisomerase 2 inhibitors

Monday 19 May 2008

Topoisomerase 2 inhibitors are associated with therapy-related acute myeloid leukemia (t-AML) with 11q23 abnormalities, but therapy-related acute promyelocytic leukemia (t-APL) is less common, and documentation of nine cases of t-APL after mitoxantrone therapy for MS suggests a specific association.


- Ramkumar B, Chadha MK, Barcos M, Sait SN, Heyman MR, Baer MR. Acute promyelocytic leukemia after mitoxantrone therapy for multiple sclerosis. Cancer Genet Cytogenet. 2008 Apr 15;182(2):126-9. PMID: 18406875