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22q11 LOH

Monday 19 May 2008

Tumors

- meningiomas (#18474292#)

Target genes

- BCR (breakpoint cluster region)
- RAB36 (a member of RAS oncogene family)
- GNAZ [guanine nucleotide binding protein (G protein), alpha-z polypeptide]
- RTDR1 (rhabdoid tumor deletion region gene 1)

References

- Wozniak K, Piaskowski S, Gresner SM, Golanska E, Bieniek E, Bigoszewska K, Sikorska B, Szybka M, Kulczycka-Wojdala D, Zakrzewska M, Zawlik I, Papierz W, Stawski R, Jaskolski DJ, Och W, Sieruta M, Liberski PP, Rieske P. BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q within a new minimal deletion region. Cancer Genet Cytogenet. 2008 May;183(1):14-20. PMID: #18474292#