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FCGR2A

MIM.146790 1q21-q23

Monday 19 May 2008

Receptors for the Fc portion of IgG (FCGRs) play an essential role in the protection of the organism against foreign antigens by removing antigen-antibody complexes from the circulation.

FCGRs receptors are present on monocytes, macrophages, neutrophils, natural killer (NK) cells, and T and B lymphocytes, and they participate in diverse functions such as phagocytosis of immune complexes and modulation of antibody production by B cells.

Pathology

- variants in susceptibility to:

References

- Paiva M, Marques H, Martins A, Ferreira P, Catarino R, Medeiros R. FcgammaRIIa polymorphism and clinical response to rituximab in non-Hodgkin lymphoma patients. Cancer Genet Cytogenet. 2008 May;183(1):35-40. PMID: 18474295